TABLE 4.
Factors affecting OS and PFS.
| Parameters | OS | PFS | ||||||
|---|---|---|---|---|---|---|---|---|
| HR | 95% CI | p | HR | 95% CI | p | |||
| lower | higher | lower | higher | |||||
| Univariable Cox regression | ||||||||
| Age (60 vs. 60y) | 1.176 | 0.483 | 2.862 | 0.721 | 0.904 | 0.377 | 2.168 | 0.820 |
| BCLC (C vs. B) | 1.870 | 0.769 | 4.546 | 0.167 | 1.440 | 0.599 | 3.460 | 0.415 |
| Sex (Male vs. Female) | 3.036 | 0.942 | 9.778 | 0.063 | 1.870 | 0.642 | 5.448 | 0.251 |
| ECOG performance status (2 vs. 0–1) | 12.076 | 3.496 | 41.710 | <0.001 | 4.151 | 1.830 | 9.416 | 0.001 |
| Child-Pugh class (B vs. A) | 10.580 | 2.566 | 42.628 | 0.001 | 3.262 | 1.183 | 9.000 | 0.022 |
| PVTT | 7.623 | 2.076 | 27.990 | 0.002 | 3.219 | 1.171 | 8.851 | 0.023 |
| Intrahepatic metastasis | 2.952 | 1.110 | 7.848 | 0.030 | 1.560 | 0.634 | 3.838 | 0.333 |
| Extrahepatic metastasis | 15.629 | 3.532 | 69.147 | <0.001 | 8.858 | 2.441 | 32.139 | 0.001 |
| Multivariable Cox regression | ||||||||
| Child-Pugh class (B vs. A) | 1.360 | 0.186 | 9.938 | 0.762 | 0.861 | 0.149 | 4.982 | 0.867 |
| ECOG performance status (2 vs. 0–1) | 2.592 | 0.852 | 7.888 | 0.094 | 1.666 | 0.580 | 4.782 | 0.343 |
| Intrahepatic metastasis | 1.418 | 0.438 | 4.595 | 0.560 | 0.747 | 0.232 | 2.410 | 0.625 |
| PVTT | 5.555 | 1.259 | 24.503 | 0.024 | 2.969 | 0.844 | 10.445 | 0.090 |
| Extrahepatic metastasis | 7.336 | 1.108 | 48.562 | 0.039 | 7.932 | 1.351 | 46.573 | 0.022 |
OS: overall survival; HR: hazard ratio; CI: confidence interval; PFS: progression-free survival.