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. 2021 Oct 18;12:722907. doi: 10.3389/fphar.2021.722907

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Copyright © 2021 Yang, An, Wang, Gao, Lin, Chen, Deng, Xu, Li, Zhang, Sun, Hou and Wu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Oxytocin attenuates ventilation-induced lung injury-related pathological changes in the mouse model. Pathological changes in mouse lung tissues are observed using HE staining by light microscopy magnification ×200. (A) Control group. (B) Control + OT group. (C) VILI group. (D) OT + VILI group. (E) L-368,899 + OT + VILI group. (F) The lung histopathological scores are presented. The data are presented as the means ± SD (n = 5). ***p < 0.001 compared with the Control and Control + OT groups, ^### p < 0.001 compared with the VILI group, and ⁺⁺⁺ p < 0.001 compared with the OT + VILI group. OT, oxytocin; SD, standard deviation; VILI, ventilation-induced lung injury.