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. 2021 Oct 18;12:740529. doi: 10.3389/fphar.2021.740529

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Copyright © 2021 Cheng, Jin, Li, Pei and Shu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cardiovascular defects in CML TKI treated zebrafish embryos. (A) Live imaging of embryos treated with the indicated concentrations of TKIs from 2 to 4 dpf. Arrows indicate cardiac edema. Scale bar: 500 µm. (B) Confocal imaging of vessel defects in TKI treated Tg(flk:GFP) embryos. Red arrow: dorsal aorta; white arrow: posterior cardinal vein; yellow arrow: subintestinal vein. At least two biological repeats were performed. Numbers indicate (number of embryos with shown phenotype/total number of embryos analyzed). Scale bar: 50 µm. (C) Cross-section of ponatinib-treated embryos. Nt: neural tube; Gt: gut; red arrow: dorsal aorta; white arrow: posterior cardinal vein. Scale bar: 50 µm. (D) TEM analysis of ponatinib-treated embryos. White arrow: aortic endothelial cell junctions. Scale bar: 2 µm.