FIGURE 3.

Evaluation of potential cardiovascular toxicity of clinical stage TKIs that are efficacious against T315I. (A) Morphology of embryos treated with the indicated TKIs at 4 dpf. Assays were performed as described in Figure 1A. Arrows indicate cardiac edema. Scale bar: 500 µm. (B) Confocal imaging of vessel phenotypes of embryos treated with the indicated TKIs. Embryos were treated and analyzed as describe in Figure 1B. Red arrow: dorsal aorta; white arrow: posterior cardinal vein. Numbers are the sum of two independent biological repeats. Scale bar: 50 µm.