Figure 9.

Avian egg yolk antibodies. (A) Entries of publications in PubMed with the keyword “immunoglobulin y” since 1990. (B) Structure of IgY. Shown are the domains of IgY with the two heavy chains (light blue) containing four constant domains (C_H1-4) and one variable domain (V_H), and two light chains (light grey) with one constant (C_L) and one variable domain (V_L). The heavy and light chains are covalently connected by disulfide bonds. The IgY is further subdivided in the antigen binding fragment (Fab) and fragment crystallisable (Fc). On the right the glycosylation sites are indicated with the detected glycan types. M9 is depicted as a representative of oligomannose type. Representative glycans for complex types are listed in Table 2 and depicted in Figure 3B . Created with BioRender.com.