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. 2021 Oct 18;12:773009. doi: 10.3389/fgene.2021.773009

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Copyright © 2021 Huang, Zhao, Wu, Li, Wang, Fu, Zhang, Bi, Li, Wang, Guo, Zhang, Wu, Li, Xu, Han, Wang, Lei, Qiu, Li, Li, Dai and Yuan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Functional network and biological progress of HL-related genes. (A) Functional network of closely related HL-related genes based on the STRING database. Three independent networks were identified by k-means clustering (N1 red, N2 green, and N3 blue). Nodes are colored to show the associations, and the thickness of lines connecting nodes indicates the strength of the association between nodes. (B) GO enrichment analysis for the contribution of genes in three independent networks N1, N2, and N3 to the functional signaling pathways.