Figure 1.

Selective neural pathway targeting of thalamostriatal neurons arising from the PF and CL. The highly efficient retrograde gene transfer (HiRet)-IL-2Rα-GFP vector is injected into the dorsal striatum (DS) and transported retrogradely through axons to various brain regions, in which the expression of the IL-2Rα-GFP transgene is induced. ITX is then treated into the PF and CL, resulting in the elimination of thalamostriatal neurons expressing the transgene in the PF and CL, respectively. Arrows show retrograde axonal transport of the viral vector. Dotted lines indicate the removal of the corresponding neural pathways. HiRet, highly efficient retrograde gene transfer; IL-2Rα, interleukin-2 receptor α-subunit; GFP, green fluorescent protein; ITX, immunotoxin; PF, parafascicular nucleus; CL, central lateral nucleus.