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Current checkpoint inhibitors with regulatory approval.
| Target | Checkpoint Inhibitor | Year of first FDA approval |
|---|---|---|
| PD-1 | Pembrolizumab | 2014 |
| Nivolumab | 2014 | |
| Cemiplimab | 2018 | |
| Dostarlimab | 2021 | |
| PD-L1 | Atezolizumab | 2016 |
| Durvalumab | 2017 | |
| Avelumab | 2017 | |
| CTLA-4 | Ipilimumab | 2011 |
