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. 2021 Oct 18;12:737764. doi: 10.3389/fphar.2021.737764

FIGURE 6.

FIGURE 6

Effect of SiPE treatment on oxidative stress/antioxidant biomarkers in HF/STZ-induced diabetic encephalopathic rats. SiPE treatment at doses of 50, 100 or 200 mg/kg caused significant decrease in (A) brain malondialdehyde (MDA) levels compared to DECA group. SiPE treatment reversed HF/STZ induced reduction in (B) brain glutathione peroxidase (GPx), (C) reduced glutathione (GSH), (D) superoxide dismutase (SOD) and (E) catalase (CAT). Data are presented as mean ± SD (n = 6) and one-way ANOVA test was applied. **p < 0.001 indicates statistical significance compared to NCA group. ##p < 0.001, &&p < 0.01 and $$p < 0.05 indicate statistical significance compared to DECA group.