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. 2021 Oct 18;9:739944. doi: 10.3389/fcell.2021.739944

FIGURE 2.

FIGURE 2

WW domain-containing E3 ubiquitin protein ligase 1 knock out alleviates simulated microgravity-induced cardiac function decline. (A,B) Echocardiographic assessment of ejection fraction (EF) and fractional shortening (FS) of WT and WWP1 knockout (KO) mice after 6 weeks of tail suspension. (C–F) Body weight, heart weight, tibia length, and the ratio of heart weight to tibia length of wild-type (WT) and WWP1 KO mice after 6 weeks of tail suspension. Data represent the means ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001. Ctrl, control; TS, tail suspension; WT, wild-type mice; KO, knockout.