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. 2021 Oct 18;12:707690. doi: 10.3389/fimmu.2021.707690

Table 3.

Association of PADI4 SNPs with RA by HLA-type.

Controls (n = 533) Anti-CCP-positive RA (n = 309) Anti-CCP-negative RA (n = 136)
pp pq qq pp pq qq OR 95% CI p-value pp pq qq OR 95% CI p-value
rs74058715
HLA-DRB1*04+ 1 161 32 0 207 20 0 0.44 [0.23;0.84] 0.01 47 3 0 0.31 [0.09;1.08] 0.06
HLA-DRB1*01+ 2 75 8 0 29 6 0 2.35 [0.69;8.01] 0.17 21 1 0 0.58 [0.06;5.13] 0.62
Other HLA-types 229 27 1 42 5 0 1.02 [0.37;2.85] 0.96 60 4 0 0.51 [0.17;1.49] 0.22
rs11203367
HLA-DRB1*04+ 1 71 92 30 65 115 47 1.32 [0.99;1.77] 0.06 12 33 5 1.11 [0.67;1.82] 0.69
HLA-DRB1*01+ 2 26 40 17 11 20 4 0.70 [0.38;1.30] 0.26 7 14 1 0.72 [0.34;1.52] 0.39
Other HLA-types 87 121 49 17 21 9 1.07 [0.68;1.70] 0.76 18 36 10 1.05 [0.71;1.55] 0.82
rs1748033
HLA-DRB1*04+ 1 105 74 14 94 104 29 1.54 [1.13;2.12] 0.007 20 28 2 1.28 [0.75;2.16] 0.36
HLA-DRB1*01+ 2 35 39 9 15 17 3 0.78 [0.40;1.50] 0.46 12 9 1 0.64 [0.29;1.44] 0.29
Other HLA-types 110 124 23 27 15 5 0.85 [0.50;1.43] 0.54 23 35 6 1.20 [0.78;1.84] 0.41
rs2240335
HLA-DRB1*04+ 1 77 96 20 106 98 23 0.81 [0.59;1.11] 0.18 21 26 3 0.91 [0.53;1.54] 0.72
HLA-DRB1*01+ 2 37 36 10 20 11 4 0.78 [0.41;1.49] 0.46 6 16 0 1.16 [0.55;2.47] 0.70
Other HLA-types 116 117 24 20 20 7 1.13 [0.69;1.83] 0.63 31 28 5 0.90 [0.58;1.38] 0.63

CCP, cyclic citrullinated peptide; RA, rheumatoid arthritis; HLA, human leukocyte antigen; p, major allele; q, minor allele; OR, odds ratio; 95% CI, 95% confidence interval. Logistic regression with adjustment for age, sex, ever smoking, carriage of PTPN22 R620W, and carriage of HLA-DRB1*04 or HLA-DRB1*01. Values marked in bold indicate 95% CI excluding 1.00 and p<0.05.

1Including heterozygotes carrying both HLA-DRB1*04 and HLA-DRB1*01; adjusted for the number of HLA-DRB1*04 alleles.

2Excluding heterozygotes carrying both HLA-DRB1*04 and HLA-DRB1*04; adjusted for the number of HLA-DRB1*01 alleles.