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. 2021 Oct 18;15:723295. doi: 10.3389/fncel.2021.723295

Figure 6.

Figure 6

Acidification of extracellular solution downregulates the excitability of caps−lpH+ neurons due to inhibition of T-type current. (A) The representative traces showing an increase in the AP threshold and conversion of ADP to AHP after a change of pH in the extracellular solution from 7.4 (black trace) to 6.5 (gray trace). The APs were evoked by the threshold current injections. (B,C) The pooled results demonstrate a significant increase of the AP threshold and conversion of ADP to AHP, when pH of the extracellular solution was changed from 7.4 to 6.5. (D,E) Inhibition of T-type current via acidification of extracellular solution. The representative traces of T-type current for the same cell evoked by a depolarization step from −100 to −50 mV at pH of the extracellular solution 7.4 (black trace), 7.0 (dark gray trace), and 6.5 (gray trace). The pooled results demonstrating significant inhibition of T-type current at pH 6.5. ***p < 0.001 and *p < 0.05.