Table 2.

Free binding energy (ΔG) and binding affinity (Pkd) of compounds 1, 2, 13, and 14 and selected known anti-melanin compounds with mushroom versus human tyrosinase

	Mushroom tyrosinase			Human tyrosinase
Cp. no.	IC50 (μM)	ΔG (Kcal/mol)	Pkd	ΔG (Kcal/mol)	Pkd
UOSC-1	0.01	−8.10	6.0	−7.73	5.73
UOSC-2	0.0074	−9.13	6.76	−7.82	5.79
UOSC-13	0.0086	−8.07	5.98	−7.36	5.45
UOSC-14	0.0099	−8.13	6.02	−7.73	5.72
Kojic acid	0.23	−5.78	4.28	–	–
Cinnamic acid	–	−7.84	–	–	–
Thiosemicarbazone	–	−7.40	–	–	–
Umbeliferone	–	−7.52	–	–	–
Reservatrol	–	−7.40	–	–	–
Chalcone	–	−8.61	–	−8.96	–