Figure 3.

Variation of GA progression and distribution as a function of retinal eccentricities (N = 237 eyes). The error bar represents 95% CIs for the mean. The red line represents the trendline. (A) We divided the retina into seven topographic zones using concentric circles (centered at the fovea) with a 0.5-mm increment in radius (up to 3.5 mm). (B) Local GA BERs increased as a function of retinal eccentricity (P < 0.001). The GA BER was 0.10 mm/y (95% CI, 0.08–0.12; n = 149 eyes) in zone 1 and increased by 2.4-fold to 0.24 mm/y (95% CI, 0.18–0.31; n = 54 eyes) in zone 7. (C) We calculated the percentage of retinal area affected by GA as the GA area in each zone divided by the total retinal area in the corresponding zone. As the retinal eccentricity increased from 0 mm to 3.5 mm, the percentage of retinal area affected by GA decreased from 49.3% to 2.3%. On average, GA affected approximately 50% of the retina within 1 mm from the foveal center; by comparison, GA affected less than 15% of the retina beyond 2-mm retinal eccentricity.