Figure 4.

The effect of immunomodulatory medication in subsequent pregnancies after a diagnosis of chronic histiocytic intervillositis (CHI). (A) Change in CHI lesion severity in pregnancies treated with or without immunomodulatory medication, compared to the participant's first placenta diagnosed with CHI from a previous pregnancy. Severity of CHI was determined by pathologist's report. Immunomodulatory treatment refers to a regimen including one or both of prednisolone and hydroxychloroquine in combination with either aspirin, heparin, or both. Pregnancies without immunomodulatory treatment were untreated or received aspirin or heparin or both. (B) Rate of infants liveborn and still living (past 28 days of life) in subsequent pregnancies related to change in CHI severity. *p < 0.05; **p < 0.01.