Table 1.
Demographics and obstetric and medical history of women with a diagnosis of chronic histiocytic intervillositis (CHI).
| Index CHI | 1st subsequent pregnancy | 2nd subsequent pregnancy | |
|---|---|---|---|
| N participants | 33 | 28 | 11 |
| N fetuses | 34 | 30 | 12 |
| Maternal age (years) | 32 (19–38) | 34 (22–41) | 37 (26–40) |
| BMI | 26 (20–47) | 27 (20–47) | 27 (20–40) |
| Ethnicity | |||
| White British | 26 (78.8%) | ||
| Asian | 6 (18.2%) | ||
| Black African | 1 (3.0%) | ||
| Lifestyle | |||
| Smoker | 3 (9.4%) | 1 (3.6%) | 0 |
| Unknown | 1 | ||
| Alcohol consumption | 0 | ||
| Unknown | 1 | ||
| Obstetric history | |||
| Previous livebirths | 0 (0–5) | ||
| Previous losses | 0 (0–4) | ||
| Primigravida | 11 (33.3%) | ||
| ART pregnancy | 4 (12.1%) | 1 (3.6%) | 0 |
| Twin pregnancy | 1 (3.0%) | 2 (7.1%) | 1 (9.1%) |
| Medical history | |||
| Autoimmune disease | 4 (12.1%) | ||
| Pre-existing hypertension | 2 (6.1%) | ||
| Anti-nuclear antibodies | 3 (17.7%) | ||
| Untested | 16 | ||
| Lupus anticoagulant | 1 (3.9%) | ||
| Untested | 7 |
Index pregnancy was defined as a participant's first pregnancy diagnosed with CHI by placental histopathological examination following poor outcome. Subsequent pregnancies refer to those following diagnosis. Continuous variables are presented as median (range) and categorical variables N (percentage). ART, assisted reproductive technology; BMI, body mass index.