Table 1.
Correlation between clinical characteristics and genomic status of stroma.
| Characteristics | Any mutation (n = 50) | Mutant KRAS (n = 50) | Mutant TP53 (n = 50) | Co-mutants KRAS and TP53 (n = 50) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Positive (n = 39) | Negative (n = 11) | p | Positive (n = 28) | Negative (n = 22) | p | Positive (n = 24) | Negative (n = 26) | p | Positive (n = 21) | Negative (n = 29) | p | ||
| Age, years | |||||||||||||
| Median | 66 | 65 | 0.3325 | 68 | 62.5 | 0.0036* | 68.5 | 63.5 | 0.0101* | 69 | 63 | 0.0029* | |
| Gender, n (%) | |||||||||||||
| Male | 23 (59) | 7 (64) | 0.9444 | 15 (54) | 15 (68) | 0.2952 | 13 (54) | 17 (65) | 0.4186 | 10 (48) | 20 (69) | 0.1283 | |
| Female | 16 (41) | 4 (36) | 13 (46) | 7 (32) | 11 (46) | 9 (35) | 11 (52) | 9 (31) | |||||
| Differentiation, n (%) | |||||||||||||
| Poor | 19 (49) | 6 (55) | 0.7328 | 14 (50) | 11 (50) | 1.0000 | 13 (54) | 12 (46) | 0.5713 | 11 (52) | 14 (48) | 0.7745 | |
| Other | 20 (51) | 5 (45) | 14 (50) | 11 (50) | 11 (46) | 14 (54) | 10 (48) | 15 (52) | |||||
| Clinical stage, n (%) | |||||||||||||
| I | 22 (56) | 3 (27) | 0.0878 | 15 (54) | 10 (45) | 0.5688 | 15 (63) | 10 (38) | 0.0894 | 12 (57) | 13 (45) | 0.3900 | |
| II-IV | 17 (44) | 8 (73) | 13 (46) | 12 (55) | 9 (37) | 16 (62) | 9 (53) | 16 (55) | |||||
| Tumor size, n (%) | |||||||||||||
| >4 cm | 5 (13) | 2 (18) | 0.9686 | 4 (14) | 3 (14) | 0.7302 | 4 (17) | 3 (12) | 0.9091 | 4 (19) | 3 (10) | 0.6438 | |
| ≤4 cm | 34 (87) | 9 (82) | 24 (86) | 19 (86) | 20 (83) | 23 (88) | 17 (81) | 26 (90) | |||||
| Lymph node, n (%) | |||||||||||||
| Positive | 14 (36) | 5 (45) | 0.8219 | 11 (39) | 8 (36) | 0.8327 | 8 (33) | 11 (42) | 0.5137 | 7 (33) | 12 (41) | 0.5629 | |
| Negative | 25 (64) | 6 (55) | 17 (61) | 14 (64) | 16 (67) | 15 (58) | 14 (67) | 17 (59) | |||||
| Nerve invasion, n (%) | |||||||||||||
| Positive | 32 (82) | 9 (82) | 0.6697 | 24 (86) | 17 (77) | 0.6888 | 21 (88) | 20 (77) | 0.5457 | 18 (86) | 23 (79) | 0.8346 | |
| Negative | 7 (18) | 2 (18) | 4 (14) | 5 (23) | 3 (12) | 6 (23) | 3 (14) | 6 (21) | |||||
| Vascular invasion, n (%) | |||||||||||||
| Positive | 13 (33) | 8 (73) | 0.0464* | 12 (43) | 9 (41) | 0.8898 | 9 (38) | 12 (46) | 0.5357 | 9 (53) | 12 (41) | 0.9168 | |
| Negative | 26 (67) | 3 (27) | 16 (57) | 13 (59) | 15 (62) | 14 (54) | 12 (57) | 17 (59) | |||||
*Statistical significance.