Table 3.
AKI in Cohorts of Hospitalized Adult (≥18 Years) Patients Infected With Respiratory Viral Infections That Do Not Bind or Downregulate ACE2.
| Publication | Total (n) |
ICU admission (n, % of total) |
Shock (n, % of total) | Vasopressor use (n, % of total) | RRT (n, % of ICU) | RRT (n, % of total) | AKI (n, % of ICU) | AKI (n, % of total) | DIED + AKI (n, % of AKI) | DIED (n, % of ICU) | DIED (n, % of total) |
|---|---|---|---|---|---|---|---|---|---|---|---|
| (A) MERS-CoV | |||||||||||
| Arabi et al 115 | 12 | 12 (100) | 5 (42) | 8 (67) | 7 (58) | 7 (58) | 7 (58) | 7 (58) | 7 (58) | 7 (58) | |
| Arabi et al 116 | 330 | 330 (100) | 262 (79) | 262 (79) | 161 (49) | 161 (49) | 161 (49) | 161 (49) | 131 (81) | 217 (66) | 217 (66) |
| Totals MERS-CoV | 372 | 342 (100) | 267 (78) | 270 (79) | 168 (49) | 168 (49) | 168 (49) | 168 (49) | 131 (81) | 224 (65) | 224 (65) |
| (B) Influenza (other than H1N1, H7N9) | |||||||||||
| Dovč et al 117 | 28 | 28 (100) | 19 (68) | 12 (43) | 12 (43) | 23 (82) | 23 (82) | 8 (35) | 8 (29) | 8 (29) | |
| Totals Influenza (not H1N1 or H7N9) | 28 | 28 (100) | n/a | 19 (68) | 12 (43) | 12 (43) | 23 (82) | 23 (82) | 8 (35) | 8 (29) | 8 (29) |
| (C) Non-ACE2-associated virus totals | |||||||||||
| MERS-CoV | 372 | 342 (100) | 267 (78) | 270 (79) | 168 (49) | 168 (49) | 168 (49) | 168 (49) | 131 (81) | 224 (65) | 224 (65) |
| Influenza (not H1N1 or H7N9) |
28 | 28 (100) | 19 (68) | 12 (43) | 12 (43) | 23 (82) | 23 (82) | 8 (35) | 8 (29) | 8 (29) | |
| Totals Non ACE2 viruses | 370 | 370 (100) | 267 (78) | 289 (78) | 180 (49) | 180 (49) | 191 (52) | 191 (52) | 139 (76) | 232 (63) | 232 (63) |
Note. AKI = acute kidney injury; ACE2 = angiotensin converting enzyme 2; ICU = intensive care unit; RRT = renal replacement therapy; MERS-CoV = Middle East Respiratory Syndrome Coronavirus.