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. 2021 Oct 18;15:732499. doi: 10.3389/fnins.2021.732499

FIGURE 2.

FIGURE 2

Dual independent PD and sleep state detectors. Detector operates in embedded fashion in each hemisphere independently. (A) Schematic drawing of lead locations indicating right hemisphere cortical sensing paddle; right STN stimulation lead and implanted pulse generator (IPG). Detector activity depicted in top 3 plots. (B) Schematic of the left hemisphere mirrors the right, bottom 3 plots show detector activity. (A,B) During hours in which the patient is awake the detector control signal (blue line) tracks parkinsonian motor signs using a narrowband gamma cortical signal (thought to indicate a pro-dyskinetic state). In this case stimulation cycles between 2.6 mA (if high levels of gamma detected) and 3.2 mA (low levels of gamma) in the right hemisphere (2.2–2.4 mA on the left). If sleep is detected (red line) by cortical alpha + theta control signal, stimulation is held at 2.6 mA (right) or 2.2 mA (left). Current is shown in green line. Time of day (24 h clock) is on x-axis.