Table 1.
Studies assessing the effect of platelet-rich plasma (PRP) treatment in patients with thin endometrium in vitro fertilization.
| Year of Publication | Country | Year of Study | RCT | Objects | Sample Size | Intervention | Control | Time of PRP Infusion | Transfer Type | Outcome Measures | Effects | Reference | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Case | Control | Case (After PRP treatment) | Control (Before PRP treatment) | P Value* | |||||||||||||
| 2015 | China | March 2014 to June 2014 | No | Women aged 31-39 with thin endometrium (<7 mm) after standard HRT | 5 | / | HRT+Intrauterine infusion of 0.5-1 ml of PRP | / | On the 10th day of HRT cycle (another dose of infusion of PRP was perfomed 72h later if the endometrial thickness was not satisfied) | FET | Endometrial thickness | Reached 7mm with one or two doses | 5/5 | 0/5 | / | (23) | |
| Clinical pregnancy | 5/5 | 0/5 | / | ||||||||||||||
| Live birth | 4/5 | 0/5 | / | ||||||||||||||
| 2017 | Iran | September 2015 to May 2016 | No | Women with a history of inadequate endometrial growth (<7 mm) in FET | 10 | / | HRT+Intrauterine infusion of 0.5ml PRP | / | On the 11-12th day and repeated on 13-14th day of HRT cycle | FET | Endometrial thickness | Reached 7mm with one dose | 0/10 | 0/10 | / | (24) | |
| Reached 7mm with two infusions | 10/10 | 0/10 | / | ||||||||||||||
| Chemical pregnancy | 5/10 | 0/10 | / | ||||||||||||||
| Clinical pregnancy | 4/10 | 0/10 | / | ||||||||||||||
| 2018 | Iran | September 2016 to January 2017 | Yes | Women aged 18-42 with thin endometrium (<7 mm) | 40 | 43 | HRT+Intrauterine infusion of 0.5-1.0ml of PRP | Underwent ET without intrauterine administration | On the 13th day of HRT cycle | FET | Endometrial thickness (mm) | 8.67 ± 0.64 | 8.04 ± 0.27 | 0.001 | ↑ | (25) | |
| Clinical pregnancy (per-cycle) | 13/40 (32.5%) | 6/43 (14.0%) | 0.044 | ↑ | |||||||||||||
| Implantation rate | 21% | 9.37% | 0.002 | ↑ | |||||||||||||
| Ongoing pregnancy (per-cycle) | 11/40 (27.0%) | 6/43 (14.0%) | 0.127 | (–) | |||||||||||||
| 2019 | Iran | 2016 to 2017 | Yes | Women who had a history of canceled frozen-thawed embryo transfer cycle due to a thin endometrium (<7 mm) | 30 | 30 | HRT+Intrauterine infusion of 0.5ml of PRP | Sham catheter | On day 11-12 and was repeated after 48 h | FET | Endometrial thickness | One dose | 5.993 ± 0.701 | 5.453 ± 0.823 | 0.63 | (–) | (26) |
| Two doses | 7.213 ± 0.188 | 5.767 ± 0.973 | < 0.001 | ↑ | |||||||||||||
| Chemical pregnancy | 12/30(40%) | 2/30(6.7%) | 0.031 | ↑ | |||||||||||||
| Clinical pregnancy | 10/30(33.3%) | 1/30 (3.3%) | 0.048 | ↑ | |||||||||||||
| 2019 | China | July 2015 to July 2016 | No | Women aged under 40 with thin endometrium (<7 mm) | 34 | 30 | HRT+Intrauterine infusion of 0.5-1.0ml of PRP | Underwent ET without intrauterine administration | On the 10th day of HRT cycle | FET | Endometrial thickness (mm) | 7.65 ± 0.22 | 6.52 ± 0.31 | 0.013 | ↑ | (22) | |
| Clinical pregnancy | 15/34 (44.12%) | 6/30(20%) | 0.036 | ↑ | |||||||||||||
| Implantation rate | 19/34(27.94%) | 7/30 (11.67%) | 0.018 | ↑ | |||||||||||||
| 2019 | South Korea | December 2015 to June 2017 | No | Women age of 20–45 years who had a history of two or more failed IVF cycles and refractory thin endometrium (<7mm) | 20 | / | HRT+Intrauterine infusion of 0.7-1.0ml of PRP | / | On day 10 and was repeated at 3 day intervals until the EMT reached 7 mm, 3 days before ET | FET | Endometrial thickness (mm) | 6.0 ± 1.1 | 5.4 ± 0.8 | 0.070 | (–) | (27) | |
| Clinical pregnancy | 6/20 | 0/20 | 0.020 | ↑ | |||||||||||||
| Live birth | 4/20 | 0/20 | 0.106 | (-) | |||||||||||||
| Implantation rate | 7/55 | 0/52 | 0.015 | ↑ | |||||||||||||
| 2020 | India | July 2018 to September 2019 | No | Women aged 27 to 39 years, suffering from primary or secondary infertility with thin endometrium (<7 mm) | 32 | / | HRT+ Instillation of 4ml PRP(1ml in each wall of the uterine cavity) into the endomyometrial junction | / | 7–10 days after the injection of leuprolide (on day 16 of OCP), 22-27days before ET | FET | Endometrial thickness | ≥7 mm (embryo transfer done) | 24/32(75%) | 0/32 | / | (28) | |
| 6–7 mm (embryo transfer not done) | 4/32(12.5%) | 0/32 | / | ||||||||||||||
| <6 mm no improvement (embryo transfer not done) | 4/32(12.5%) | 0/32 | / | ||||||||||||||
| Serumβ-hCG positive | 12/24(50%) | 0/24 | / | ||||||||||||||
| Clinical pregnancy | 10/24(41.66%) | 0/24 | / | ||||||||||||||
| Live birth | 5/24(20.83%) | 0/24 | / | ||||||||||||||
| 2020 | Brazil | January to December 2018 | No | Patients with endometrium thickness below 5 mm during preparation for FET | 21 | / | HRT+Intrauterine infusion of 0.5ml of PRP | / | PRP was administered on the 14th to 17th day of HRT every second day, for a total of three infusions. | FET | Clinical pregnancy | 0.667 | 0/21 | / | (29) | ||
| Ongoing pregnancy or live birth | 0.54 | 0/21 | / | ||||||||||||||
*: ↑, increase; (-), no significant change.