Table 2.

Univariate and multivariate analysis of factors associated with survival and recurrence in two independent cohorts of human CRC.

Clinical Variables	Time to Recurrence		Overall Survival
	HR (95% CI)	P value	HR (95% CI)	P value
Univariate analysis
Age (≤60 vs > 60)	1.027 (0.771-1.368)	0.853	1.146 (0.877-1.496)	0.766
Gender (female vs male)	0.934 (0.724-1.206)	0.601	0.927 (0.716-1.199)	0.562
Tumor size (≤5 cm vs >5 cm)	1.073 (0.826-1.395)	0.596	0.597 (0.439-0.821)	0.318
Tumor differentiation (well/moderate vs poor)	0.50 (0.387-0.647)	<0.001	0.474 (0.366-0.614)	<0.001
Tumor invasion (I-II vs III)	0.585 (0.432-0.791)	0.001	0.597 (0.439-0.821)	0.001
Lymph node metastasis (absent vs present)	0.190 (0.144-0.250)	<0.001	0.174 (0.131-0.231)	<0.001
Distant metastasis (absent vs present)	0.121 (0.085-0.173)	<0.001	0.099(0.069-0.1143)	<0.001
AJCC stage (I-II vs III)	0.173 (0.131-0.229)	<0.001	0.159 (0.120-0.210)	<0.001
GOLM1 expression (negative vs positive)	0.569 (0.439-0.738)	<0.001	0.555(0.427-0.7220)	<0.001
Multivariate analysis
Tumor differentiation (well/moderate vs poor)	0.844 (0.632-1.127)	0.251	0.851(0.634-1.140)	0.279
Tumor invasion (I-II vs III-IV)	0.748 (0.540-1.035)	0.080	0.789(0.567-1.098)	0.160
Lymph node metastasis (absent vs present)	1.175 (0.536-2.576)	0.686	0.937(0.428-2.055)	0.872
Distant metastasis (absent vs present)	0.334 (0.225-0.497)	<0.001	0.275(0.183-0.412)	<0.001
AJCC stage (I-II vs III)	0.334 (0.244-0.497)	<0.001	0.223 (0.099-0.505)	<0.001
GOLM1 expression (negative vs positive)	0.194 (0.086-0.438)	0.002	0.641 (0.485-0.846)	0.002