Figure 4.

Hey1 interference suppresses and Hey1 overexpression promotes tumor growth and lung metastases of A375 cells in vivo. (A) These graphs show the tumor xenografts 4 weeks after ectopic-subcutaneous implantation in nude mice. (B) Tumour growth curve. (C) Representative images of primary implanted tumor mass of mice sacrificed at 4 weeks. (D) Representative hematoxylin and eosin images of lung specimens. Black arrow indicates metastatic lung nodule. Data are shown as mean ± SD. *P<0.05, **P<0.01.