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Knockdown of LBX2-AS1 alleviates the growth of orthotopic glioma in nude mice. (A) 2.5×105 luciferase-labeled U87 cells transfected with sh-LBX2-AS1#1 or sh-NC were stereotactically implanted in nude mice. (B) Bioluminescence images of nude mice. (C) IHC staining of Ki-67, p-STAT3 and LIF in mouse brain sections of glioma. Scale bar = 50 μm. (D) Kaplan-Meier survival curves of orthotopic glioma mice. (E) Schematic diagram of mechanism of LBX2-AS1 regulating EMT in glioma.
