Table 2.
Univariate and multivariate analyses of prognostic factors for OS
| Univariate analysis | Multivariate analysis | ||||||
|---|---|---|---|---|---|---|---|
| Variables | HR | 95% CI | P | Variables | HR | 95% CI | P |
| PNI (≥47 vs. <47) | 0.394 | (0.246-0.632) | <0.001 | PNI (≥47 vs. <47) | 0.413 | (0.270-0.710) | 0.001 |
| Hemoglobin | Hemoglobin | ||||||
| <94 | 1 | <94 | 1 | ||||
| 94-122 | 0.46 | (0.240-0.882) | 0.019 | 94-122 | 0.35 | (0.119-0.208) | 0.046 |
| ≥122 | 0.296 | (0.153-0.573) | <0.001 | ≥122 | 0.673 | (0.474-0.956) | 0.027 |
| Age (≥69 vs. <69) | 1.054 | (1.022-1.088) | 0.001 | Age (≥69 vs. <69) | 1.986 | (1.167-3.380) | 0.011 |
| LDH (ratio >1 vs. ≤1) | 1.973 | (1.246-3.123) | 0.004 | Liver invasion (yes vs. no) | 4.868 | (1.825-12.988) | 0.002 |
| Neutrophils (≥3.84 vs. <3.84) | 1.948 | (1.199-3.167) | 0.007 | CNS invasion (yes vs. no) | 2.543 | (1.218-5.310) | 0.013 |
| IPI (HIR/HR vs.LR/LIR) | 1.299 | (1.071-1.576) | 0.008 | WBC (≥5.8 vs. <5.8) | 2.033 | (0.853-4.847) | 0.109 |
| β2-MG (elevated vs. normal) | 2.315 | (1.169-4.586) | 0.016 | ||||
| Liver invasion (yes vs. no) | 3.08 | (1.329-7.136) | 0.009 | ||||
| GNRI (≥106.26 vs. <106.26) | 0.675 | (0.482-0.944) | 0.022 | ||||
| CNS invasion (yes vs. no) | 1.936 | (1.097-3.416) | 0.023 | ||||
| WBC (≥5.8 vs. <5.8) | 1.81 | (1.098-2.983) | 0.02 | ||||
| BMI (<24 vs. ≥24) | 0.871 | (0.773-0.982) | 0.024 | ||||
| BCL-2 (positive vs. negative) | 2.037 | (0.096-0.317) | 0.043 | ||||
| BM involvement (yes vs. no) | 1.385 | (0.600-3.198) | 0.445 | ||||
Note: PNI: prognostic nutritional index; GNRI: geriatric nutritional risk index; IPI: International Prognostic Index; HIR: high intermediate risk; HR: high risk; LR: low risk; LIR: low intermediate risk; WBC: White blood cell count; β2-MG: β2-microglobulin; CNS invasion: Central nervous system invasion. BM involvement: Bone marrow involvement.