Table 3. General Information About Articles and Their Methodology.

First Author	Year	Country	Patient Num	Mean Age	Lost Patient	Study Design	Blindness	VAS	Questionnaire Time	Peak Pain	Statistical Analysis
Artés-Ribas	2013	Spain	20	26.4	0	Split-mouth	Single blind	10	T1, before placing the separator; T2, 5 min after placement and laser applied, 6 h, 24 h, 48 h, and, 72 h after separator placement	6 and 24 h (T3–T4)	Microsoft Excel, Statgraphics® Plus, Multivariate analysis
Almallah	2020	Syria	36	17.44	Not mentioned	Split-mouth	Double blind	10	1, 6, 24, 48, and 96 h after separation	24h	Microsoft® Excel, Minitab, v. 17 and IBM SPSS, t tests, ANOVA, LSD
Eslamian	2014	Iran	37	24.97	Not mentioned	Split-mouth	Single blind	10	(hour 0, before laser irradiation); after 6, 24, and 30 h; and on the days 3, 4, 5, 6, and 7	6 and 30 h	(SPSS17, the mean and standard deviation of the VAS scores, Wilcoxon’s signed-rank test, Mann–Whitney U test, Friedman’s test
Almallah	2016	Syria	36	18.4	Not mentioned	Split-mouth		10	1, 6, 24, 48, 96 hours after separation.	Single irradiation: 4h double irradiation: 48h	Microsoft Excel, Minitab® V17, SPSS®V17, t-test. ANOVA, LSD