Table 2. Cox regression analyses of hyperhomocysteinemia for cardiovascular disease events and all-cause death.

	Cardiovascular disease events			All-cause death
	HRs (95% CI)	P-value		HRs (95% CI)	P-value
Model 1: adjusted for sex and age. Model 2: adjusted for variables in model 1 plus smoking status, alcohol consumption, diabetes mellitus, physical activity, low-density lipoprotein cholesterol, high-sensitivity C-reactive protein, estimated glomerular filtration rate, antihypertensive treatment and regular supplementation of folic acid. CI: confidence interval; HRs: hazard ratios.
Crude	1.85 (1.33−2.59)	< 0.001		2.09 (1.46−2.99)	< 0.001
Model 1	1.65 (1.17−2.34)	0.004		1.48 (1.03−2.13)	0.035
Model 2	1.45 (1.01−2.08)	0.045		1.55 (1.04−2.30)	0.030