Table 3. Hazard ratios with 95% CI of cardiovascular disease events, stroke events, and coronary events according to the presence of hyperhomocysteinemia and hypertension.
| HT(−)HHcy(−) | HT(−)HHcy(+) | HT(+)HHcy(−) | HT(+)HHcy(+) | Ptrend-value | |
| *Presented as hazard ratios with 95% CI. &Presented as per 1,000 person-years. Model 1: adjusted for sex and age. Model 2: adjusted for variables in model 1 plus smoking status, alcohol consumption, diabetes mellitus, physical activity, low-density lipoprotein cholesterol, high-sensitivity C-reactive protein, estimated glomerular filtration rate, antihypertensive treatment and regular supplementation of folic acid. HHcy: hyperhomocysteinemia; HT: hypertension. | |||||
| Cardiovascular disease events | |||||
| Case | 12 | 35 | 36 | 85 | |
| Person-year | 1076.95 | 1445.08 | 1486.55 | 2073.26 | |
| Incident rate& | 11.14 | 24.22 | 24.22 | 41.00 | |
| Crude | 1.00 | 2.23 (1.16−4.29)* | 2.21 (1.15−4.25)* | 3.80 (2.07−6.95)* | < 0.001 |
| Model 1 | 1.00 | 1.99 (1.03−3.84)* | 2.01 (1.04−3.88)* | 3.10 (1.68−5.73)* | 0.010 |
| Model 2 | 1.00 | 1.76 (0.91−3.44)* | 1.82 (0.92−3.63)* | 2.44 (1.28−4.65)* | 0.041 |
| Stroke events | |||||
| Case | 10 | 25 | 23 | 55 | |
| Person-year | 1079.86 | 1455.85 | 1502.88 | 2097.70 | |
| Incident rate& | 9.26 | 17.17 | 15.30 | 26.22 | |
| Crude | 1.00 | 1.89 (0.91−3.93)* | 1.68 (0.80−3.54)* | 2.90 (1.48−5.70)* | 0.006 |
| Model 1 | 1.00 | 1.79 (0.85−3.75)* | 1.64 (0.78−3.46)* | 2.69 (1.35−5.34)* | 0.017 |
| Model 2 | 1.00 | 1.62 (0.77−3.43)* | 1.38 (0.63−3.05)* | 2.07 (1.01−4.29)* | 0.176 |
| Coronary events | |||||
| Case | 1 | 11 | 15 | 31 | |
| Person-year | 1100.88 | 1487.25 | 1522.98 | 2180.80 | |
| Incident rate& | 0.91 | 7.40 | 9.85 | 14.21 | |
| Crude | 1.00 | 8.37 (1.11−64.85)* | 10.94 (1.45−82.81)* | 16.14 (2.20−118.24)* | 0.015 |
| Model 1 | 1.00 | 6.25 (0.80−48.62)* | 8.73 (1.15−66.23)* | 10.15 (1.38−74.80)* | 0.088 |
| Model 2 | 1.00 | 5.59 (0.71−43.80)* | 8.07 (1.03−63.07)* | 8.33 (1.10−63.11)* | 0.177 |