Table 1. Baseline demographic and clinical characteristics grouped by presence of a family (paternal, maternal or sibling) history of premature coronary heart disease (before age 60 years).
| Variables | Family history of premature coronary heart disease | ||
| Absent (n = 6,440) | Present (n = 2,206) | P-value | |
| Data are presented as means ± SD or n (%). *Presented as median (interquartile range). | |||
| Age, yrs | 47.1 ± 12.1 | 48.1 ± 12.1 | < 0.001 |
| Women | 2,877 (44.7%) | 1,126 (51.0%) | < 0.001 |
| White race | 6,092 (94.6%) | 2,130 (96.6%) | < 0.001 |
| Systolic blood pressure, mmHg | 128.4 ± 20.1 | 129.8 ± 21.4 | 0.008 |
| Diastolic blood pressure, mmHg | 84.0 ± 11.3 | 84.5 ± 11.9 | 0.066 |
| Hypertension | 2,722 (42.3%) | 991 (44.9%) | 0.030 |
| Smoking | 4,104 (63.7%) | 1,413 (64.1%) | 0.783 |
| Body mass index, kg/m2 | 25.9 ± 4.2 | 26.2 ± 4.4 | 0.018 |
| Body mass index ≥ 30 kg/m2 | 937 (14.6%) | 397 (18.0%) | < 0.001 |
| Fasting glucose, mg/dL | 98.5 ± 21.7 | 100.3 ± 27.0 | 0.004 |
| Diabetes mellitus | 225 (3.5%) | 132 (6.0%) | < 0.001 |
| Low-density lipoprotein cholesterol, mg/dL | 144.9 ± 41.5 | 152.0 ± 44.0 | < 0.001 |
| High-density lipoprotein cholesterol, mg/dL | 51.2 ± 16.5 | 50.0 ± 16.5 | 0.003 |
| Total cholesterol, mg/dL | 221.8 ± 46.3 | 229.3 ± 52.4 | < 0.001 |
| Triglycerides, mg/dL | 122 (85−185)* | 130 (91−192)* | 0.024 |