Table 4.

Multivariable models for ALK+ vs. EGFR+ NSCLC and vs. EGFR-/ALK- NSCLC.

Predictor (vs. EGFR+)		OR (95% CI)	P-value
Age at diagnosis	>60 vs ≤60	0.19 (0.08 – 0.43)	<0.01
Air bronchograms	Yes vs No	0.11 (0.03 – 0.42)	<0.01
Lung metastasis	Yes vs No	0.08 (0.03 – 0.19)	<0.01
Pleural metastasis	Yes vs No	2.99 (1.31 – 6.83)	0.01
Lymphangitic carcinomatosis	Yes vs No	5.63 (2.06 – 15.35)	<0.01
Bone metastasis	Lytic vs None	1 (0.42 – 2.39)	>0.99
	Sclerotic vs None	4.04 (1.27 – 12.87)	0.02
Brain metastasis	Yes vs No	0.34 (0.15 – 0.76)	0.01
Distant lymphadenopathy	Yes vs No	18.43 (3.53 – 96.13)	<0.01
Predictor (vs. EGFR-/ALK-)		OR (95% CI)	P-value
Age at diagnosis	>60 vs <=60	0.16 (0.06 – 0.43)	<0.01
Smoke status	Never vs Ever	12.15 (4.24 – 34.81)	<0.01
Air bronchograms	Yes vs No	0.07 (0.02 – 0.34)	<0.01
Lung metastasis	Yes vs No	0.07 (0.02 – 0.21)	<0.01
Lymphangitic carcinomatosis	Yes vs No	5.22 (1.5 – 18.23)	0.01
Adrenal metastasis	Yes vs No	0.13 (0.03 – 0.56)	0.01
Liver metastasis	Yes vs No	8.26 (1.79 – 38.15)	0.01
Bone metastasis	Lytic vs None	1.58 (0.49 – 5.15)	0.45
	Sclerotic vs None	10.84 (1.67 – 70.28)	0.01

Abbreviations: OR, odds ratio; CI, confidence interval