Table 2.
Frequencies of mtDNA variants defining mtDNA haplogroups among controls and pooled cases
| MtDNA variations | mtDNA haplogroups | Controls (n = 615) [n(%)] | Pooled cases (n = 536) [n(%)] | P value (χ2)a | Adjusted P valueb | OR (95% CI)b |
|---|---|---|---|---|---|---|
| A663G | A | 39 (6.34) | 48 (8.96) | 0.117 | 0.060 | 1.567 (0.980–2.500) |
| 8281-8289d c | B | 118 (19.19) | 87 (16.23) | 0.217 | 0.150 | 0.781 (0.557–1.093) |
| C5178a c | D | 176 (28.62) | 110 (20.52) | 0.002 | 0.012 | 0.681 (0.504–0.919) |
| A249d/T6392C/G10310A | F (F1 + F3) | 129 (20.98) | 77 (14.37) | 0.004 | 0.002 | 0.639 (0.483–0.847) |
| A4833G | G | 16 (2.60) | 32 (5.97) | 0.005 | < 0.001 | 4.384 (2.103–9.137) |
| T9824C | M7 | 33 (5.37) | 41 (7.65) | 0.119 | 0.519 | 1.181 (0.712–1.957) |
| A4715G | M8 (M8a + C + Z) | 36 (5.85) | 59 (11.01) | 0.002 | 0.009 | 1.876 (1.167–3.021) |
| T3394C | M9 | 18 (2.93) | 30 (5.60) | 0.027 | 0.005 | 2.618 (1.339–5.128) |
| G16274A | M2 | 8 (1.30) | 5 (0.93) | 0.399 | 0.896 | 0.899 (0.180–4.484) |
| T16126C | M3 | 10 (1.63) | 7 (1.30) | 0.616 | 0.466 | 0.572 (0.128–2.567) |
| T16311C | M10 | 9 (1.46) | 6 (1.12) | 0.592 | 0.418 | 0.509 (0.099–2.610) |
| G6023A | M13 | 4 (0.65) | 4 (0.75) | 1.000 | 0.514 | 0.566 (0.102–3.137) |
| T489C/C10400T/T14783C/G15043A | M* | 1 (0.16) | 1 (0.19) | 1.000 | NA | |
| G5417A/C16257a/C16261T | N9a | 11 (1.79) | 27 (5.04) | 0.003 | 0.004 | 3.401 (1.486–7.752) |
| T1391C/T16311C | R1 | 7 (1.14) | 2 (0.37) | 0.187 | 0.219 | 0.353 (0.067–1.859) |
aχ2-test or Fisher's exact test. Bonferroni corrected P < 0.05/n (n = 15)
bP value and ORs (95% CIs) determined by multivariate logistic regression analysis, adjusted for age, gender, smoking and diseases (including cardiopulmonary diseases, diabetes, obesity and hypertension determined through clinical and radiographic examinations)
cThe letter “d” indicates nucleotide deletion, the letter "a" indicates nucleotide transversion
NA not available