List of abbreviations
| Abbreviation | Definition |
|---|---|
| 4EBP1 | Eukaryotic initiation factor 4E binding protein |
| 5-HT | Serotonin |
| AD | Antidepressant drug |
| Akt | Protein kinase B (PKB) |
| AMPAR | α-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate receptor |
| AMPK | AMP-activated protein kinase |
| Bax | Bcl-2-associated X protein |
| Bcl2 | B-cell lymphoma 2 |
| BDNF | Brain-derived neurotrophic factor |
| CNS | Central nervous system |
| CREB | Cyclic adenosine monophosphate response element-binding protein |
| CSF | Cerebrospinal fluid |
| CUS | Chronic unpredictable stress |
| Deptor | DEP-domain containing mTOR-interacting protein |
| DSM 5 | Diagnostic and Statistical Manual of Mental Disorders, 5th edition |
| eEF2K | Eukaryotic elongation factor-2 kinase |
| eIF4B | Eukaryotic translation initiation factor 4B |
| eIF4E | Eukaryotic translation initiation factor 4E |
| ERK | Extracellular signal-regulated kinase |
| FKBP12 | FK506-binding protein of 12 kDa |
| GABA | Gamma aminobutyric acid |
| GATOR | GAP activity toward Rags |
| GluN2B | Glutamate receptor subunit epsilon-2 |
| GluR1 | Glutamate receptor subunit 1 |
| GSK-3β | Glycogen synthase kinase-3 |
| HAMD | Hamilton Rating Scale for Depression |
| HIP | Hippocampus |
| HPA-axis | Hypothalamic-pituitary-adrenal axis |
| IDS-SR | Inventory of Depressive Symptomatology |
| IGF | Insulin-like growth factor |
| IRS | Insulin receptor substrate-1 |
| LKB1 | Liver Kinase B1 |
| MADRS | Montgomery–Åsberg Depression Rating Scale |
| MDD | Major depressive disorder |
| mLST8 | Mammalian lethal with Sec13 protein 8 |
| MOA | Mechanism of action |
| mTOR | Mammalian target of rapamycin |
| mTORC1/2 | Mammalian target of rapamycin complex 1/complex 2 |
| NMDAR | N-methyl-D-aspartate receptor |
| p70S6K | Ribosomal protein S6 kinase |
| p75NTR | To neurotrophin receptor P75 |
| PBMC | Peripheral blood mononuclear cell |
| PDCD4 | Programmed cell death 4 protein |
| PFC | Prefrontal cortex |
| PI3K | Phosphatidylinositol-3-kinase |
| PRAS40 | Proline-rich Akt substrate of 40 kDa |
| PSD95 | Postsynaptic density protein 95 |
| Rag | Ras-related GTPases |
| Raptor | Regulatory-associated protein of TOR |
| REDD1 | Regulated in development and DNA damage responses 1 |
| RSK1 | Ribosomal S6 kinase |
| S6 | Ribosomal protein S6 |
| SKAR | S6K1 aly/REF-like target |
| SNP | Single-nucleotide polymorphism |
| SNRI | Serotonin-norepinephrine re-uptake inhibitor |
| SSRI | Selective serotonin re-uptake inhibitor |
| TCA | Tricyclic antidepressant |
| TrkB | Tropomyosin-related kinase B receptor |
| TSC1/2 | Tuberous sclerosis complexes 1 and 2 |
| Tti1/Tel2 | TELO2 Interacting Protein 1 |
| VDCC | Voltage-gated calcium channel |