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In vitro cellular uptake and antitumor efficacy of ALA-PTX NPs. (A) Uptake of ALA-PTX NPs by MCF-7, MCF-7/ADR and HepG2 cells. *p<0.05, **p<0.01, compared with PTX injection; $p<0.05, $$p<0.01, compared with the ALA-PTX solution. (B) Endocytosis inhibitors co-incubated with ALA-PTX NPs in MCF-7, MCF-7/ADR and HepG2 cell to explore the endocytosis pathways. **p<0.01, compared with the cellular uptake of the no inhibitor treatment group (control).
