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. 2021 Oct 27;16:7269–7281. doi: 10.2147/IJN.S331578

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© 2021 Xu et al.

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Intracellular dissolution of ALA-PTX NPs. (A) Fluorescence emission spectra of DiO&DiI-ALA-PTX NPs. Green line: ALA-PTX NPs dissolved in water at 0h; Black line: ALA-PTX NPs dissolved in water at 12h; Blue line: ALA-PTX NPs dissolved in water at 24h; Red line: ALA-PTX NPs dissolved in ethanol at 0h. (B) FRET images of MCF-7/ADR cells incubated with DiO&DiI-ALA-PTX NPs for 2, 4, 6, 12, 24h. (C) FRET ratio of MCF-7/ADR cells incubated with DiO&DiI-ALA-PTX NPs for 2, 4, 6, 12, 24h. **p<0.01, compared with the 2h group.