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. 2021 Oct 28;218(12):e20192070. doi: 10.1084/jem.20192070

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© 2021 Isringhausen et al.

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Figure 7. — Combined blockage of type I and II IFN signaling prevents persistent decline in HSC functionality induced by infection. (A) Schematic experimental layout for ELDA repopulation assays. m, months. (B) Linear regression analysis for the transplantation, with indicated numbers representing ELDA estimates for HSC functionality. Table indicates values for 95% confidence intervals for each experimental group. (C) Individual engraftment analysis showing overall CD45.1 donor engraftment (black circle), as well as donor lineage distribution in T cell (green), B cell (blue), and granulocyte (red) engraftment as percentage of total CD45.1 engraftment. Mice were considered engrafted when PB CD45.1 engraftment was >0.5% in myeloid (Gr1⁺) and lymphoid lineages (T and B). Empty columns indicate total CD45.1 donor engraftment <0.5%. Transplantation was performed in seven to nine transplanted mice per condition (two independent experiments). Statistics were analyzed using Pearson’s χ² test, and P values are shown.