Video 5.
Inhibition of type I IFN signaling prevents infection-induced damage to CARc and ECM networks. 3D confocal microscopy of thick femur slices either from uninfected control mice (ctrl) or mice 14 dpi treated with PBS or type I IFN-blocking antibody (a-IFNαR). CXCL12-GFP shown in green, segmented CARc spots (whole diaphysis image) and collagen IV fibers (zoomed-in image) shown in red, color-coded CARc density map shown at the end of the video. Thickness of tissue slices was 60 µm for whole diaphysis images and 30 µm for zoomed-in images.