Figure 1.

Multimodal imaging of high-grade glioma (HGG). (a) Axial T2-weighted imaging shows an infiltrative mass lesion centred in the left temporal lobe with mass effect and uncal displacement. (b) T1-weighted post-contrast imaging shows heterogeneous post-contrast enhancement in the lesion. (c) The lesion demonstrates patchy areas of diffusion restriction, as demonstrated in the apparent diffusion coefficient maps. (d) T1-weighted post-contrast image overlaid by the amide proton transfer-weighted (APTw) image demonstrates multifocal areas of high APT ratios in the lesion. The upper limit of the colour scale has been adopted to show the largest APT ratios in the periphery of the lesions (∼4.3 in the index case).