Table 1.

Comparative Epidemiology or Kawasaki Disease PIMS and Toxic Shock Syndrome.

Kawasaki disease	PIMs	Toxic shock syndrome
It is an acute, self-limiting vasculitis affecting medium-sized vessels, especially the coronary arteries.	PMIS is associated to SARS-CoV-2 virus or to the post-infection inflammatory effects of the disease, considering that these types of disease appear after the peak of SARS-CoV-2 infection. Produce hyperinflammation.	It is a toxin-mediated disease that is caused by toxin-producing streptococci or S. aureus. These superantigens bypass the normal pathway for activation of T cells resulting in over-activation of cytokines and inflammatory cells.
Frequently affects children under 5 years old	Older children and adolescents	In non-menstrual settings occurs at any age
Its incidence in Northeast Asian countries including Japan, South Korea, China, and Taiwan is 10 to 30 times higher than that in the United States and Europe	There is a lack of understanding to why these cases appear more in Europe, United States, Italy, France, and not in China or Japan) where COVID-19 first started.	The incidence tends to be higher in the winter and is more prevalent in developing countries.
Its etiology is unclear, with no specific infectious cause.	PMIS is associated to SARS-CoV-2 virus	It is most commonly caused by a toxigenic strain of Staphylococcus aureus or Group A Strep (Streptococcus pyogenes).
Risk factors: To be a boys tend to develop more this disease and the entity of being from Asia or pacific islands	Risk factor: to have a present or resent COVID-19 infection. To have comorbidities like obesity or asthma.	Risk factors include superabsorbent tampon use, nasal packing, post-operative wound infections, recent influenza infection, as well as immunocompromised states.