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. 2021 Oct 29;9(10):e003163. doi: 10.1136/jitc-2021-003163

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© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

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Summarizing figure. The left side of the figure shows the mechanism of action of IgA and IgG antibodies against GD2. IgA antibodies mediate killing of neuroblastoma cells with neutrophils as effector cells, while IgG antibodies do so via NK cells and CDC. On the right side of the figure, effects on GD2-expressing peripheral neurons are shown. Here, IgG activates the complement system, leading to pain. In contrast, IgA does not. CDC, complement-dependent cytotoxicity; NK, natural killer.