HFpEF Pathophysiology Overview
Overview of the structural, functional, and hemodynamic derangements associated with heart failure with preserved ejection fraction (HFpEF) as targeted by device-based solutions currently under development. The 4 main categories of medical devices for HFpEF are atrial shunts, left ventricular (LV) expanders, mechanical circulatory support (MCS) devices, and electrical and neurostimulators. EDPVR = end-diastolic pressure-volume relationship; ESPVR = end-systolic pressure-volume relationship; LA = left atrial; LAP = left atrial pressure; LAV = left atrial volume; LVP = left ventricular pressure; LVV = left ventricular volume.