Table 4.

Time-dependent multivariate analysis of the prognostic factors for patients with GISTs

	Hazard ratio	p
At Surgery
Age		0.013
≥ 50	1·00 (reference)
<50	2.31 (1.20,4.44)
Sex		0.031
Female	1·00 (reference)
Male	2.00 (1.07,3.76)
Tumor size, cm		0.152
< 5.0	1·00 (reference)
≥ 5.0	1.69 (0.83,3.46)
Tumor location		0.259
Gastric	1·00 (reference)
Nongastric	1.42 (0.77,2.62)
Mitotic Index, per 50 HPFs		0.014
≤ 5.0	1·00 (reference)
>5.0	2.10 (1.17,3.78)
Tumor rupture		0.046
No	1·00 (reference)
Yes	2.41 (1.02,5.71)
1 yr
Age		0.025
≥ 50	1·00 (reference)
<50	2.17 (1.10,4.26)
Sex		0.042
Female	1·00 (reference)
Male	1.93 (1.02,3.64)
Mitotic Index, per 50 HPFs		0.005
≤ 5.0	1·00 (reference)
>5.0	2.34 (1.29,4.25)
3 yr
Sex		0.042
Female	1·00 (reference)
Male	1.93 (1.02,3.64)
Mitotic Index, per 50 HPFs		0.005
≤ 5.0	1·00 (reference)
>5.0	2.34 (1.29,4.25)
5 yr
Mitotic Index, per 50 HPFs		0.023
≤ 5.0	1·00 (reference)
>5.0	3.25 (1.17,8.97)
6 yr
	None