Table 1.

The relative abundance of the top 10 gut bacterial genera at the phylum and genus level (%) from both young and middle-aged APP/PS1 mice

Level	YTGCon	YTGLf	Level	ATGCon	ATGLf
Phylum			Phylum
Firmicutes	55.43 ± 4.00	57.74 ± 4.18	Firmicutes	17.19 ± 5.70	8.30 ± 1.64
Bacteroidetes	37.62 ± 4.77	37.37 ± 4.17	Bacteroidetes	7.54 ± 5.72	12.21 ± 4.69
Proteobacteria	3.80 ± 0.66	2.49 ± 0.18	Verrucomicrobia	8.00 ± 5.47	3.17 ± 2.60
Actinobacteria	1.48 ± 0.24	1.17 ± 0.23	Proteobacteria	3.42 ± 1.69	0.52 ± 0.12*
Deferribacteres	0.54 ± 0.05	0.44 ± 0.04	Actinobacteria	0.41 ± 0.16	0.68 ± 0.29
Verrucomicrobia	0.36 ± 0.09	0.19 ± 0.05	[Thermi]	0.52 ± 0.51	0.00 ± 0.00
Tenericutes	0.19 ± 0.08	0.21 ± 0.06	TM7	0.05 ± 0.03	0.19 ± 0.12
Fusobacteria	0.17 ± 0.10	0.05 ± 0.03	Tenericutes	0.05 ± 0.02	0.01 ± 0.00
Deinococcus-Therms	0.07 ± 0.05	0.01 ± 0.01	Acidobacteria	0.03 ± 0.03	0.00 ± 0.00
Cyanobacteria	0.05 ± 0.04	0.01 ± 0.01	Cyanobacteria	0.01 ± 0.01	0.00 ± 0.00
Genus			Genus
Lachnospiraceae_NK4A136_group	3.05 ± 0.26	3.68 ± 0.45	Akkermansia	8.00 ± 5.47	3.17 ± 2.60
Ruminiclostridium	2.69 ± 0.18	3.48 ± 0.61	Bacteroides	4.79 ± 4.36	0.32 ± 0.20
Ruminiclostridium_9	2.83 ± 0.18	3.27 ± 0.30	Oscillospira	1.64 ± 0.56	0.22 ± 0.07*
Bacteroides	3.88 ± 0.75	1.71 ± 0.29*	Desulfovibrio	1.62 ± 1.56	0.24 ± 0.11
Rikenellaceae_RC9_gut_group	2.49 ± 0.48	2.64 ± 0.32	Allobaculum	0.61 ± 0.29	1.03 ± 0.57
Blautia	1.96 ± 0.21	2.13 ± 0.20	Faecalibacterium	1.18 ± 1.16	0.02 ± 0.02
Oscillibacter	1.47 ± 0.15	2.37 ± 0.28*	Coprococcus	1.03 ± 0.77	0.03 ± 0.01*
Roseburia	1.72 ± 0.24	2.03 ± 0.28	Ruminococcus	0.63 ± 0.15	0.19 ± 0.04*
Alistipes	2.09 ± 0.14	1.64 ± 0.08*	Lachnospira	0.57 ± 0.57	0.01 ± 0.01
EU457075_g	1.69 ± 0.21	1.25 ± 0.17	Sutterella	0.53 ± 0.51	0.01 ± 0.01

N = 7 animals per group. * P < 0.05 versus YTGCon or ATGCon group, respectively by the Mann–Whitney U test.