TABLE 2.
Different CNV patterns of m6A regulatory genes and three frequently mutated genes occurred in BLCA samples (n = 363)
| Gene | Diploid | Deep deletion | Shallow deletion | Copy number gain | Amplification | CNV sum | Percentage | |
|---|---|---|---|---|---|---|---|---|
| Eraser | ALKBH5 | 125 | 9 | 177 | 49 | 3 | 238 | 65.56% |
| FTO | 174 | 3 | 115 | 69 | 2 | 189 | 52.07% | |
| Writer | METTL3 | 171 | 4 | 110 | 73 | 5 | 192 | 52.89% |
| METTL14 | 182 | 1 | 147 | 30 | 3 | 181 | 49.86% | |
| METTL16 | 120 | 7 | 190 | 45 | 1 | 243 | 66.94% | |
| RBM15 | 222 | 1 | 59 | 76 | 5 | 141 | 38.84% | |
| WTAP | 145 | 4 | 181 | 33 | 0 | 218 | 60.06% | |
| ZC3H13 | 155 | 20 | 118 | 68 | 2 | 208 | 57.30% | |
| Reader | YTHDF1 | 117 | 0 | 23 | 220 | 3 | 246 | 67.77% |
| YTHDF2 | 215 | 0 | 79 | 66 | 3 | 148 | 40.77% | |
| YTHDF3 | 122 | 0 | 28 | 200 | 13 | 241 | 66.39% | |
| YTHDC1 | 193 | 1 | 116 | 46 | 7 | 170 | 46.83% | |
| YTHDC2 | 143 | 6 | 187 | 25 | 2 | 220 | 60.61% | |
| Mutated genes | TP53 | 119 | 10 | 192 | 41 | 1 | 244 | 67.22% |
| TNN | 165 | 1 | 26 | 149 | 22 | 198 | 54.55% | |
| MUC16 | 172 | 1 | 121 | 65 | 4 | 191 | 52.62% |