Table 2.

Classification Criteria for Multifocal Choroiditis with Panuveitis

Criteria

1. Multifocal choroiditis with

a. Oval or round lesions AND

b. Predominant lesion size >125 μm

AND

2. Characteristic appearance

a. “Punched-out atrophic” chorioretinal scars OR

b. Active lesions with more than minimal vitreous inflammation

AND

3. Inflammatory lesions and/or characteristic scars involving the mid-periphery or periphery with or without posterior pole involvement

Exclusions

1. Positive serologic test for syphilis using a treponemal test

2. Evidence of sarcoidosis (either bilateral hilar adenopathy on chest imaging or tissue biopsy demonstrating non-caseating granulomata)

3. In tuberculosis-endemic regions or tuberculosis-exposed individuals*, evidence of infection with Mycobacterium tuberculosis

a. Histologically- or microbiologically-confirmed infection with M. tuberculosis† OR

b. Positive interferon-Ɣ release assay (IGRA)‡ OR

c. Positive tuberculin skin test§

^*Testing not needed in tuberculosis non-endemic regions.

^†E.g. biopsy, fluorochrome stain, culture, or polymerase chain reaction based assay.

^‡E.g. Quantiferon-gold or T-spot.

^§E.g. purified protein derivative; a positive result should be >10 mm induration