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. 2021 Mar 27;49(12):e67. doi: 10.1093/nar/gkab199

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© The Author(s) 2021. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — Accuracy of parameter estimation by k-Seq. (A) Dependence of accuracy (ratio of estimated to true ) on mean counts across all simulated samples (including the unreacted pool sample). The dashed lines correspond to ratios as labeled. Ratios >100-fold or <0.01-fold are shown at the borders of the plot. (B) Fraction of sequences for which the CI-95, estimated using bootstrapping or using triplicates, includes the true values, for sequences with different mean counts across all samples. Sequences were ranked by mean counts (from highest to lowest) and binned in sets of 25 000 sequences. Each data point indicates the fraction of CI-95 that includes the true values in each bin.

Inline graphic — Accuracy of parameter estimation by k-Seq. (A) Dependence of accuracy (ratio of estimated to true ) on mean counts across all simulated samples (including the unreacted pool sample). The dashed lines correspond to ratios as labeled. Ratios >100-fold or <0.01-fold are shown at the borders of the plot. (B) Fraction of sequences for which the CI-95, estimated using bootstrapping or using triplicates, includes the true values, for sequences with different mean counts across all samples. Sequences were ranked by mean counts (from highest to lowest) and binned in sets of 25 000 sequences. Each data point indicates the fraction of CI-95 that includes the true values in each bin.