Table 3.

Mean ± standard deviation plasma concentrations of BKIs –1812, –1814, and –1649. Taken from the 4^th day (day 9 PI) of dosing C. parvum infected adult female IFN-γ KO mice.

BKI-1812	60 mg/kg	30 mg/kg	15 mg/kg
Time sampled	Plasma concentration (μM)
predose	15.7 ± 11.7	2.1 ± 0.2	1.5 ± 0.3
1 h post dose	258.9 ± 22.5	111.4 ± 71	49.4 ± 26.3
2 h post dose	250.5 ± 48.4	115.7 ± 65.9	37.4 ± 19.3
4 h post dose	170.1 ± 110.8	54.6 ± 31.7	14.1 ± 9.2
BKI-1814	60 mg/kg	30 mg/kg	15 mg/kg
Time sampled	Plasma concentration (μM)
predose	1.83 ± 1.4	0.03 ± 0.06	0.24 ± 0.2
0.5 h post dose	17.5 ± 10.7	7.1 ± 2.5	1.68 ± 0.6
1 h post dose	19.5 ± 9.8	6.88 ± 1.5	2.46 ± 0.5
2 h post dose	18.2 ± 10.2	5.86 ± 1.6	2.25 ± 0.8
BKI-1649*	60 mg/kg	30 mg/kg	15 mg/kg
Time sampled	Plasma concentration (μM)
predose	346 ± 78	113 ± 31	76 ± 1.2
0.5 h post dose	340 ± 177	110 ± 65	79 ± 44
1 h post dose	345 ± 188	111 ± 66	82 ± 46
2 h post dose	360 ± 199	134 ± 81	93 ± 51

^*BKI-1649 formed in vivo by demethylation of ether on BKI-1814