Table 4.

Cardiovascular effects of intravenous infusion in anesthetized rats (n=3). A change of ± 15% is considered biologically relevant for mean arterial pressure (MAP) or heart rate (HR). A change of ± 20% is considered biologically relevant for cardiac contractility (dP/dt@50). Plasma concentration values are listed as mean ± SEM. % values are listed as mean change relative to vehicle.

	Dose (mg/kg)	Plasma Concentration (μM)	MAP (%)	HR (%)	dP/dt@50 (%)
BKI-1812	3	1.59 ± 0.42	−2	5	5
	10	11.3 ± 0.5	4	13	10
	30	188 ± 44.1	−5	18	23
BKI-1814	3	1.74 ± 0.04	−3	−3	4
	10	6.67 ± 0.37	−4	−5	6
	30	15.3 ± 0.04	−6	−9	16