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Intrinsically disordered regions (IDRs) mediate different types of complexes. (A) Binding-coupled folding: free IDRs explore a vast conformation space (colors), but some IDRs adopt a fixed conformation when bound to a partner (gray). (B) In a fuzzy complex, the IDR is dynamic yet remains bound to its partner. (C) Nonstoichiometric complexes (clusters) can form via networked interactions between multivalent IDRs.
