How is entry into the SRX regulated?

What structural mechanisms are involved in force sensing by myosin molecules and thick filaments?

Which signaling pathways are regulated by myosin mechanobiology, and how do they become dysregulated in disease?

How do posttranslational modifications of myosin and its binding partners tune myosin function over time during development and disease pathogenesis?

How do different disease-causing mutations in myosin lead to activation of different downstream pathways?

Can myosin mutations be binned into groups that will positively respond to a given therapeutic in order to improve patient outcomes through a precision medicine approach?

How do specific mutations affect allosteric coupling within myosin, and can this information explain why these myosin variants cause a given disease?

What are the structural mechanisms of the new drugs that target myosin function?