Table 1.

Differential cytotoxicity (IC₅₀) of probe prodrugs DB289 and DB844.

Treatment		KLE	CYP1B1-HEK293T	HEK293T	HepaRG
Prodrug	α-NFa
DB289	−	54.9 ± 1.0b	57.6 ± 1.6	57.9 ± 5.4	82.5 ± 1.4
	+	84.1 ± 2.1	61.8 ± 1.6	57.4 ± 6.1	87.6 ± 2.4
DB844	−	57.9 ± 1.3	38.8 ± 0.9	37.9 ± 0.9	76.3 ± 1.6
	+	72.1 ± 1.2	37.5 ± 0.6	38.9 ± 0.9	82.2 ± 2.2

^aα-NF concentration was 10 μM.

^bValues are IC₅₀ ± standard errors after nonlinear regression analysis of quadruplicate determinations at individual concentration.