TABLE 2.
Univariate Binary Logistic Regression for Achieving SVR for Interferon-naïve Patients With HCV-associated HCC Within Milan Criteria Who Underwent Liver Transplantation
Logistic Regression |
||
---|---|---|
OR (95% CI) | P value | |
Age at diagnosis (median, IQR) | 1.03 (0.98–1.07) | 0.31 |
Sex | ||
Female | Reference | |
Male | 0.46 (0.19–1.11) | 0.08 |
Race/Ethnicity | ||
White | Reference | |
Black | 0.55 (0.27–2.09) | 0.55 |
Asian | 1.74 (0.22–13.75) | 1.74 |
Latino | 1.05 (0.44–2.51) | 1.05 |
ASA | ||
I | Reference | |
II | – | – |
III | – | – |
IV | – | – |
Functional status | ||
Independent | Reference | |
Partially dependent | 1.18 (0.58–2.40) | 0.65 |
Totally dependent | 1.14 (0.14–9.46) | 0.91 |
DAA regimen | ||
Sofosbuvir/velpatasvir | Reference | |
Ledipasvir/sofosbuvir | 0.48 (0.11–2.11) | 0.33 |
Glecaprevir/pibrentasvir | 0.24 (0.05–1.18) | 0.08 |
Other | 0.38 (0.08–1.77) | 0.22 |
Timing of DAA therapy | ||
Pre-LT | Reference | |
0–3 mo post LT | 1.42 (0.41–4.93) | 0.58 |
≥3 mo post LT | 0.36 (0.20–0.65) | <0.01 |
Received liver-directed therapy | ||
No | Reference | |
Yes | 1.33 (0.56–3.16) | 0.52 |
Deceased donor | ||
Deceased donor | Reference | |
Living donor | – | – |
HCV+ donor liver | ||
No | Reference | |
Yes | 0.65. (0.31–1.34) | 0.24 |
Any postoperative complication | ||
No | Reference | |
Yes | 0.60 (0.34–1.07) | 0.08 |
Acute rejection | ||
No | Reference | |
Yes | 1.47 (0.56–3.87) | 0.44 |
Retransplant | ||
No | Reference | |
Yes | – | |
Months on waitlist | 1.01 (0.99–1.03) | 0.38 |